Production Scientifique


  • 2017

1. A green, one-pot, three-component and microwave assisted synthesis of α-sulfamidophosphonates, Belhani Billel, Khaoula Bechlem, Grib Ismahene, Cheloufi Hadjer, Aouf Nour-Eddine, Berredjem Malika. Journal of Materials and Environmental Science. 2017, 8(x):xx.

2. A Simple, Efficient, Catalyst-Free and Solvent-Less Microwave-Assisted Process for N-Cbz Protection of Several Amines. Zneb Aouf, Rachida Mansouri, Salah Lakrout, Malika Berredjem, Nour-Eddine Aouf, Journal of the Korean Chemical Society. 2017, 61(4), DOI: 10.5012/jkcs.2017.61.4.151

3. A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation. Radia Bouasla, Khaoula Bechlem, Billel Belhani, Ismahene Grib, Nour-Eddine Aouf, Berredjem Malika. Oriental Journal of Chemistry, 2017 33(3), DOI: 10.13005/ojc/330348.

4. Ultrasonic assisted green protocol for the synthesis of sulfamides. Ismahene Grib, Billel Belhani, Khaoula Bechlem, Radia Bouasla, Nour-Eddine Aouf, Malika Berredjem. Phosphorus, Sulfur, and Silicon and the Related Elements, 2017, DOI:

5Synthesis, X-ray crystallographic and DFT studies of two new N-acylsulfonamides. Hadjer Cheloufi, Khaoula Bechlem, Wahida Boufas, Carole Barbey, Abdeslem Bouzina, Billel Belhani, Nathalie Dupont, Nour-Eddine Aouf, Malika Berredjem. Journal of Materials and Environmental science, 2017. 8, 997-1003.

6.  Enantioselective enzymatic resolution of racemic alcohols by lipases in green organic solvents Abderahmane Belafriekha,  Francesco Secundob, , , Stefano Serrab, Zeineddine Djeghaba. Tetrahedron: Asymmetry. 2017. 


  • 2016

1. A New Family of 1,2,3-Oxathiazolidine-2,2-dioxide Phosphonate Derivatives: Synthesis, Characterization and Anticancer Evaluation. Hacène K’tir, Zineb Aouf, Tan Otea Souk, Rachida Zerrouki, Malika Berredjem & Nour-Eddine Aouf. Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 192:5, 555-559. DOI:

2. Copper-(S)-N-methylpyrrolidine-2-carboxylate catalyzed N-arylation of N5H-1,2,5-thiadiazolidine 1,1-dioxides. M. Dehamchia and Z. Regaïnia. Journal of Fundamental and Applied Sciences. 20168, 1, 92-100.

2. Efficient Candida rugosa lipase immobilization on Maghnite clay and application for the production of (1R)-(−)-Menthyl acetate. Fatiha Benamia, Sabrina Benouis, Abderahmane Belafriekh, Noura Semache, Nacer Rebbani, Zeineddine Djeghaba. Chemical Papers. 2016. DOI: 10.1007/s11696-016-0080-9.

3. Docking studies of (-)-Epigallocatechin-3-gallate: A potential non-competitive pancreatic lipase inhibitor. Bouchagra, S., Benamia, F., Djeghaba, Z. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016. 7 (5), 2493.

4. Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard. Hadjer. Cheloufi · Billel. Belhani1· Tan. Sothea. Ouk · Rachida. Zerrouki· Nour-Eddine. Aouf · Malika. Berredjem. Molecular Diversity. 2016, 20, 399-405.

5. Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar ratsYassine Réggami · Hajira Berredjem · Hadjer Cheloufi · Malika Berredjem · Noureddine Bouzerna. European journal of pharmacology. 2016, 779, 122-130.

6. Charge transfer complexes of 4-isopropyl-2-benzyl-1,2,5-thiadiazolidin-3-one1,1-dioxide with DDQ and TCNE : Experimental and DFT studies. New journal of chemistry. Seridi Saida · Dinar Karim · Seridi Achour · Berredjem Malika ·Kadri Mekki. 2016, DOI: 10.1039/C5NJ03017J

7. Efficient synthesis of novel N-acylsulfonamide oxazolidin-2-ones derivatives. Abdeslem Bouzina, Ismahen Grib, Khaoula Bechlem, Billel Belhani, Nour-Eddine Aouf, Malika Berredjem. Karbala International Journal of Modern Science. 2016,(In pressxx, 1-6. DOI:

8. Greener, Efficient and Catalyst-Free Ultrasonic-Assisted Protocol for the N-Fmoc Protection of Amines. Rachida Mansouri · Zineb Aouf · Salah Lakrout · Malika Berredjem · Nour-Eddine Aouf. Journal of the Brazilian Chemical Society2016, 3, 546.

9. Ultrasound assisted green synthesis of a-hydroxyphosphonates under solvent-free conditions. Abdeslem Bouzina, Nour-Eddine Aouf, Malika Berredjem. Research on chemical intermediate. 2016. DOI: 10.1007/s11164-015-2420-8.

10. A Practical and Green Approach towards Synthesis of new N-sulfonylimines under ultrasound irradiation. Ismahene Grib, Abdeslem Bouzina, Nour-Eddine Aouf, Malika Berredjem. Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, DOI: 10.1080/10426507.2016.1138306.

11. Synthesis, characterization and spectroscopic studies of Iron (III) and Copper(II) complexes of-hydroxyl phosphonate. Dalila Fedaoui, Abdeslem Bouzina, Nour-Eddine Aouf, Yacine Bouhadja and Malika Berredjem, Der Pharma Chemica2016, 8, (1), 124-127.

12. Synthesis and antibacterial activity of new chiral N-sulfamoyloxazolidin-2-ones. Fouzia Bouchareb, Malika Berredjem, Samira Ait Kaki, Amel Bouaricha, Abdeslem Bouzina, Billel Belhani, Nour-Eddine Aouf. Journal of Chemical Science. 2016.  128, (1) , 85-91. DOI: 10.1007/s12039-015-1004-x.

13.  The Antibacterial and Cytotoxic Activities of Four New Sulfonamides Against Clinical Gram-Negative Bacteria.  Becheker Imène, Berredjem Hadjira, Boufas Wahida, Berredjem Malika. Int. J. Pharm. Sci. Rev.  Res.,  2016. 39(2), 125-133.

  • 2015

1. A greener procedure for the synthesis of a-ureidophosphonates under ultrasound irradiation. X-ray crystallographic study. Abdeslem Bouzina, Malika Berredjem, Sofiane Bouacida, Nour-Eddine Aouf. RSC Advances. 2015. DOI: 10.1039/C5RA19886K.

2. Synthesis and spectroscopic study of new substituted phosphoramidates and 1,3,2-diazaphospholidine-2,5-diones. Fouzia Bouchareb, Malika Berredjem and Nour-Eddine Aouf. Der Pharma Chemica, 2015, 7, 61.

3. Synthesis of Novel Nitrogen Mustards Containing Amino Alcohol Derivatives. Aïcha Amira, Malika Berredjem, and Nour-Eddine Aouf. Journal of Life Sciences and Technologies , 2015, 3, 65.

4. Novel, rapid and green method of phosphorylation under ultrasound irradiation and catalyst free conditions. Abdeslem Bouzina, Billel Belhani, Nour-Eddine Aouf, Malika Berredjem. RSC Advances 2015, 5, 46272.

5. Multicomponent reactions of novel α-sulfamidophosphonates synthesis Under ultrasound irradiation and catalyst-free conditions. Billel Belhani, Malika Berredjem, Nour-Eddine Aouf, Marc LeBorgne, Zouhair Bouaziz, Jacques LeBreton. RSC Adv., 2015, 5, 39324.

6. One-pot synthesis of novel oxazaphosphinanes under ultrasound irradiation and solvent-free conditions. Billel Belhani, Abdeslem Bouzina, Aouf Nour-Eddine, Berredjem Malika. Monatshefte für Chemie 03/2015. DOI:10.1007/s00706-015-1461-4.

7. Synthesis Of Novel Peptidosulfonamides Derived From Modified Oxazolidinones. Malika Berredjem, Billel Belhani, Bouzina abslem, Hadjer Cheloufi, Nour-Edddine Aouf. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2015, 6(4). 11.

8. An eco-friendly and highly efficient route for N-acylation under catalyst-free conditions. S. Ouarna, H. K’tir, S. Lakrout, H. Ghorab, Z. Aouf, M. Berredjem,  N..Aouf. Oriental Journal of Chemistry. 2015, 31 (2).

9. A Simple and highly efficient solvent and catalyst-free synthesis of novel N  sulfamoyl imines. Djemili. A,  Lakrout. S, Cheraiet. Z, Berredjem. M, Aouf. N-E. Green Chemistry Letters and Reviews, 2015. 8(1), 48.  DOI: 10.1080/17518253.2015 .1027287 .

10. Self-organizing behaviour of glycosteroidal bolaphiles: Insights into lipidic microsegregation. Xu, R., Ali-Rachedi, F. Xavier, N.M., Chambert, S., Ferkous, F., Queneau, Y., Cowling, S.J. , Davis, E.J., Goodby, J.W. Organic and Biomolecular Chemistry, 2015, 13, , 783-79.

11. In-vitro antibacterial activity of two novel sulfonamide derivatives against urinary strains of Escherichia coli. Bouacha, M., Berredjem, H., Berredjem, M., Bouzerrna, N. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2015, 6. 770-775.

12. Hydrogen bonding investigation in Pyridoxine/β-cyclodextrin complex based on QTAIM and NBO approaches  (Article). Attoui-Yahia, O. Khatmi, D., Kraim, K., Ferkous, F. Journal of the Taiwan Institute of Chemical Engineers 47, 2015, 91-98.

13. Antidiabetic and Hypolipidemic Potential of 3,4-dihydroisoquinolin-2-(1H)-sulfonamides in Alloxan induced diabetic rats H. Berredjem, Y. Reggami, M. Belaifa, M. Berredjem, N. Bouzerna. Int. J. Pharmacol. 2015, 11,3, 226-235.

14. Convenient Synthesis of Novel N-sulfonamides containing phosphonate moiety. Boufas, W , Berredjem,  Aouf, N. Phosphorus, Sulfur, and Silicon,  2015, 190, 103-111. DOI 10.1080/10426507.2014.931.998.

15. A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity. Aicha Amira, Hacene K’Tir, Souad Ouarna, Nicolas Inguimbert, Hadjira Berredjem, Malika Berredjem. Der Pharma Chemica 2015, 7(7), 213-219.

16. Fungitoxic Evaluation of New Modified Amidophosphonates (AP1, AP2) on the in vitro Growth of Two Fungal Strains. Amina Saib, Houria Berrebah, Rida Djebbar, Malika Berredjem. Research journal of environmental toxicology. 2015, 9(4), 196.

17. Ultrasond effects on the activity ans enantiosectivity of Candida Rugosa lipse in organic solvents. Abederahman Belafriekh, Fatiha Benamia, Zeineddine Djeghaba. International Journal of Chemical and Petroleum Sciences, IJCPS, 2015, 4 (2), 34-41.

  • 2014

1. A simple, rapid and efficient N-Boc protection of amines under ultrasound irradiation and catalyst-free conditions. Amira Aïcha ● K’tir Hacène ● Berredjem Malika● Aouf Nour-Eddine. Monatch. Chem.  2014 , 145, 509-515. DOI; 10.1007/s00706-013-1094-4.

2. A Simple and Eco-Sustainable Method for the Sulfonylation of Amines Under Microwave-Assisted Solvent-Free Conditions. Salah Lakrout, Hacène K’tir, Aïcha Amira, Malika Berredjem and Nour-Eddine Aouf. RSC Advances. 2014, 4, 16027. DOI: 10.1039/C4RA01346H.

3. Microware Assistity New, Efficient, and Catalyst Free for Formation of O-ter-butoxy Carbonates. K’tir, Hacène, Amira Aicha, Malika Berredjem, Aouf Nour-Eddine. Chemistry Lett. 2014.:10.1246/cl.140075.

4.  Efficient synthesis, characterization and antibacterial activity of novel N-acyclsulfonamides and sufonylureas. Cheloufi H, Berredjem M, Bouchareb, F.; Boufas, W, Aouf, N. Phosphorus, Sulfur, and Silicon and relat. elem. 2014, Accepted DOI:10.1080/10426507.2

5. Synthesis, Acylation and Antibacterial Activity of Sulfonamides SAR and DFT Studies.  W. Foufas, M. Berredjem , H. Berredem, K. Berrezag, N. Dupond , N-E. Aouf. Journal of Molecular Structure. 2014, 1074, 180-185.

6.  Cytotoxic Study of three Derivatives Amidophosphonates on Alternative cellular model Paramecium teraurelia    Saib A, Berredjem, M, Berrabeh . H, Djebbar M-R. RSC Toxicol. Res. 2014, on line DOI 10.1039/C4TX00033A

7. Novel unsymmetrically p-Acetoxyphenyl and p-hydroxyphenyl tetrathiafulvalenes: Electrohemical Proprieties and Electrical Conductivity of their Charge Complexes. D. Bouchouk, A. Bendjeddou, T. Abbaz, A, Gouasmia, N. Aouf, D. Villemin. Indian Journal of Chemistry. 2014, 53 (B). 884-889.

8. Synthesis of a new series of sulfonamides containing isatin moiety. Cheloufi. H.  , Berredjem; M.,  Aouf, N. PhytoChem & BioSub Journal. 2014,Vol. 8 (2)

9- Induction of oxidative stress in Paramecium Aurelea Expose Exposed to a novel Phosphoramidate. Hounaida Benbouzid, Malika Berredjem , Houria Berrebah,  M-Reda  Djebbar. Fresenius of Environemental Bulletin. 2014, 1-9.

10. An efficient method for the synthesis of novel N-sulfonylimines using TBAB under   solvent-  free conditions. Boufas. W.; Belhani, B.; Cheloufi, H.; K’tir, H.; Aouf;N-E, Berredjem, M. J. Chem. and  Phar. Reseach. 2014, 6 (10) 876-881.

11. Antibacterial activity of four sulfonamide derivatives against multidrug-resistant Staphylococcus aureus. I. Becheker, H. Berredjem, N. Boutefnouchet, M. Berredjem, A.Ladjama. J. Chem. and  Phar. Reseach. 2014. 6(11): 893-899

12. Synthesis and Antibacterial Activity of Novel N-Acylsulfonamides. Malika Berredjem, Fouzia Bouchareb, Samira Ait Kaki, Maazouz Dekhil, Nour-Eddine Aouf. Arabian Journal of Chemistry.  2014. DOI 10.1016/Jarabj 2013.O1.O16   in press online

13. An  efficient method  for the synthesis   of novel N-acylsulfonamides  using Tin (IV) chlorides as catalysts. F. Bouchareb,   W. Foufas, H. Cheloufi,   M. Berredjem , N-E. Aouf. Phosphorus, Sulfur, and Silicon and relat. elem. 2014189, 587-595. DOI : 10. 1080/ 104265507. 2013.

  •  2013

1. Comparaison of Artificial Neural Network (ANN) and Response Surface Mathodology (RSM) in Optimization of the Immolization Conditions for Lipase from Gandida Rugosa on Amberjet 4200 –Cl. Fatiha Benamia, Sameh Bouchagra, Youcef Saiha, Zeineddine Djeghaba, Nacer Rebani. Preparative Biochemsitry & Biotechnology. 2013, 43, 33-47.

2. Efficient Synthesis of  Modified  Sulfamides and  Cyclosulfamides  Containing Phosphonate Moieties Hessainia, Sihem, Malika Berredjem, Ouarna Souad , Cheraiet Zinelaabidine, Aouf N-E. Phosphorus, Sulfur, and Silicon and relat. elem. 2013 ,  188, 719-725.

3. A simple and eco-sustainable method for the O-Boc formation/cleavage of various phenolic structures under water-mediated/catalyst-free conditions. Cheraiet  Zinelaabidine , Hessainia, Sihem, Ouarna Souad Malika Berredjem, Aouf N-E. Green Chemistry Letters and Reviews.2013. 6, 3, 211-216. DOI:10.1080/17518253.2012.738371

4. Efficient Synthesis and anti bacterial Activity of novel cyclosulfamides. Sihem Hessainia, Fouzia Bouchareb , Wahida Foufas, Malika Berredjem,Nour-Eddine Aouf.  Rasayan J. Chem2013, Vol 6,  N°3,  175-182.

5. Host-Guest interaction Between 3,4-dihydroisoquinoline-2 (1H)-sulfonamide and b-cyclodextrin; Spectroscopic and Molecular Modeling Stucies. S. Seridi, A. Seridi, M. Berredjem, K. Mekki. Journal of Molecular Structure.  2013, 1052, 8-16. DOI 10.1016/j.molstruc.2013.08.035

6. Synthesis and Biological Activity  of New Chiral N-Acylsulfonamides Bis –oxazolidin-2-ones. R. Bouasla, H. Berredjem, A. Assia, M. Berredjem, Marc Lecouvey, Nour-Eddine Aouf. J. Heterocycl. Chem. 2013. 50 (6), 1328-1332. DOI. 10.1002/jhet 1987

7. Synthesis and structural study of N-acetyl_1,2,3,4-tetrahydroisoquinoleine-2-sulfonamide obtained by using H6P2W18O62 as acidic. C. Bougheloum, A. Messalhi, C. Barbey,  M. Berredjem, N. Dupond. Molecular Structure. 2013, 1041, 6-15. DOI :10.1016/j.molstruc.2013.02.018

8. Electrochemical Characterization of Enzymatic Impedimetic Biosensor Destect Organochlorine Pesticide : The Diclofop-Methyl. S. Baali, S. Zougar, R. Kherrat, Z. Djeghaba, F. benamia, N. Jaffrezic-Renault. Sensors & Transducers. 2013, 148, 2, 135-142.

9. Compartative  Study of Responses of two Enzymatic Biosensors Bazed on Lipase from Candida rugosa and Porcine Pancreas for Detection of Diclofop-Methyl. S. Baali, R. Kherrat S. Zougar, , Z. Djeghaba, F. Benamia, N. Jaffrezic-Renault, H, Naoufel. Sensor Lett. 2013, 11, 1-9. doi:10.1166/sl.2013.3058

10. Conventional and microwave-assisted solvent-free synthesis of fused [1,2,5]-thiadiazolo[3,4-b]quinoxaline-2,2-dioxide derivatives. M. Dehamchia, Z. Regainia.  Journal of Sulfur Chemistry.  2013 . 34, 242. DOI.10.1080/17415993.2012.729589

11. Nonlinear QSAR study of xanthone and curcuminoid derivatives as α-glucosidase inhibitors. Saihi, Y., Kraim, K., Ferkous, F., Djeghaba, Z., Azzouzi, A., Benouis, S. Bulletin of the Korean Chemical Society. 2013, 34, 1643.

  • 2012

01- Efficient Method for the  Synthesis of α-Amodophosphonates  via Micheali Arbusov Reaction. Samia Guezane Lakoud, Malika Berredjem and Nour-Eddine Aouf. Phosphorus, Sulfur, and Silicon. 2012 187:762–768. 02. Efficient Method for the Synthesis of Diazaphospholidines: Toxicological Evaluation. Fouzia Bouchareb, Sihem Hessainia, Malika Berredjem,Hounaida Benbouzid, Houria Djebbar, Nour-Eddine Aouf.  American Journal of Organic Chemistry. 2012, 2(1): 14-17. 03. Toxic Effect of Phosphoramidate on Paramecium sp. with special emphasis on respiratory metabolism growth, and regeration time. Hounaida Benbouzid, Houria Berrebah, ,Malika Berredjem, M-Reda  Djebbar. Toxicological & Environnemenal Chemistry. 2012, 1-9. 04. Ring-closing metathesis towards functionalized pentacyclic steroids. Malika Ibrahim-Ouali, Hocine Bouleghlem, Nour-Eddine Aouf. Tetrahedron Letters. 2012. 53. 1859–1862. 05. Efect of Novel Phosphoramidate on Paramecium on growth and respiratory metabolism of Paramecium aurelia. Hounaida Benbouzid, Houria Berrebah, ,Malika Berredjem, M-Reda  Djebbar. J. Nat.Sci. Biom.Med. 2012, 3, 1.48-51 06. Unprecendented Directe Oxidative Cross-Coupling of sulfahydantoins with Aldehydes via a radical sulfonate-sulfinate Conversion. Yoann Aubin, Evelina Colacino, Djamel Bouchouk, Georges Dewynter, Jean. Martinez. New J. Chem2012, 36, 1560-1563 07. A New Class of Heterocycles: 1,4,3,5-Oxathiadiazepane 4,4-dioxides.  Amel Bendjeddou, Tahar Abbaz, Zine Regainia  and Nour-Eddine Aouf. Molecules.  2012, 17, 1890-1899; doi:10.3390/molecules  17021890 08. Synthesis and Electrochemical Proprieties of Novel Unsymmetrical Bis-Tetrathifulvalenes and  Eyanoquinodimethane Electrical Conductivity of their Charge Transfert Complexes  with Tetractracyanoquinodimethane (TCNQ). Tahar Abbaz , Amel Bendjeddou,  Abdelkrim Gouasmia, Zine Regainia, Didier Villemin. Int. J.Mol. Sci. 2012, 13, 7872-7885. 09. A new series of seven-membered cyclic sulfamides containing thiophene or units. Tahar Abbaz , Amel Bendjeddou,  Abdelkrim Gouasmia, Zine Regainia, Didier Villemin. Der Chemica. Sinica. 2012, 3, (3), 717-721. 10. N-tert-Butoxycarbonylation of structurally diverse amines and sulfamides under water-mediated catalyst-free conditions. Zinelaabine Cheraiet, Souad Ouarna, Sihem Hessania, Malika Berredjem and N-E. Aouf. ISRN Organic Chemistry international, Volume 2012, Article ID 404235, 8 pages 11. Synthesis of New Fuzed Benzothiadiazepines and Macrocyclic Sulfamides Stratinfg From N,N –Disubstitud Sulfamides and N-Boc sulfamides. M. Dehamchia, Z. Regainia. ISRN Organic Chemistry international, Volume 2012, Article ID 810938, 9 pages 12. A simple and efficient green method for the deprotection of N-Boc in various structurally diverse amines under water-mediated catalyst-free conditions. Cheraiet Zinelaabidine, Ouarna Souad, Jamel Zoubir, Malika Berredjem, Aouf Nour-Eddine. International journal of chemistry, 2012,Vol. 4, No. 3, 73-79. 13. Efficient Deprotection of Boc Group in Sulfamides Using Heteropolyacid Catalyst (HPA). R. Belghiche, Zine Cheriat, Malika Berredjem,Mostefa Abbessi and N-E.Aouf. E- Journal of Chemistry. 2012, 3 (3), 305-309.

14. Synthesis and structural study of new substituted chiral sulfamoyl  oxazolidin-2-ones. C.  Barbey, R. Bouasla, M. Berredjem, N. Dupont,  N-E Aouf and M.Lecouvey, Tetrahedron. 2012, 65, 9125-9130.

15. Synthesis of Oxazolidin-2-Ones Phosphonates Derivatives:Toxic Effect on Paramecium Species. S.Ouarna, H. Berrebbah, H. Ktir, A. Amira, M. Berredjem. and N. Aouf. Rasayan J. Chem., 2012, Vol 5,  N°4,  450-455.


  crsict 2014: